Photography (Nikon)
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ICOO D70 Deluxe Edition Android Tablet
Here’s a glance at ICOO’s newest Android tablet, the D70 Deluxe Edition. The device will sport a 7.0-inch 800 x 480 capacitive multi-touch display, an ARM Cortex-A10 processor, an 8GB of storage, a microSD card slot, 2160p Super HD video playback support, WiFi, 3G module support and run on Android 2.3 OS. Unfortunately, there’s no word on pricing and release date yet. [ICOO]
Cytheris, Centre Léon Bérard and ImmunID Announce Initiation of Clinical Trial ... EON: Enhanced Online News (press release)
The trial is designed to explore the optimal schedule for delivery of CYT107 during standard capecitabine chemotherapy, with the aim of immune reconstitution and collection of preliminary data on the impact of CYT107 on severe hematological toxicity and tumor progression in second line metastatic breast cancer patients. The immunorestorative properties of IL-7, which include its ability to provide T cells to attack any residual disease, are expected to have a significant impact on survival in this patient population, where a low CD4 T cell count associated with poor receptor diversity detected before initiation of chemotherapy is a known predictive factor indicating overall survival of less than 6 months compared to almost two years for non-lymphopenic patients.
Conducted as a collaborative effort of the Centre Léon Bérard (the study sponsor), ImmunID Technologies, and Cytheris, the study, known as ELYPSE-7, is designed to evaluate whether CYT107 treatment is able to correct lymphopenia post-chemotherapy in advanced cancer patients and whether the correction of this lymphopenia by restoration of the immune system will result in a broadening of the repertoire of T cells and a reduction in the risk of severe haematological toxicity, tumor progression and early death.
The study is based on many years of research conducted by the team of Jean-Yves Blay, MD, PhD, Professor of Medicine at the Université Claude Bernard, Lyon, and the current President of the European Organization for Research and Treatment of Cancer (EORTC).
“Lymphopenia (<1000 Lymphocytes/μl) or CD4+ T cell lymphopenia (<450/μl) detected prior to initiation of chemotherapy as well as Divpenia as defined and measured by ImmunID Technologies) was associated with a short overall survival of ≤6 months. Median survival of severely divpenic patients was less than 6 months, compared to >22 months for the remaining patients who were not in this severely lymphopenic state. The outcome of the ELYPSE-7 study is thus expected to have significant implications for overall survival and tumor progression in patients with advanced cancers, including ovarian cancer, metastatic breast cancer, non-Hodgkin lymphoma, and sarcoma.“
Qualitative and quantitative alterations of local and circulating immune cells have been identified as playing an important role in breast cancer progression. In a series of studies including more than 3000 patients, Dr. Blay’s team has shown that lymphopenia is found in 20-25% of patients with advanced cancers, including 20% of untreated patients with metastatic breast cancer. In a large series of patients it was observed that lymphopenia is associated with a 20% and 50% risk of early death at 1 and 3 months and that T cell CD4 lymphopenia is also an independent risk factor for early death and toxicity in these patients.
“In a recent review article (Mackall C et al. Nat Rev Immunol. 2011 May; 11(5):330-42) entitled “Harnessing the Biology of IL-7 for Therapeutic Application”, the authors conclude that despite the impressive biological effects of IL-7 on T cell populations, the essential issue regarding clinical development of this cytokine is the need to show that the biological effects of IL-7 translate to improved clinical outcomes such as prolonged survival or cure,” said Michel Morre, DVM, President and CEO of Cytheris. “Such proof of concept can only be obtained by carrying out careful clinical trials in targeted populations who are at greatest risk owing to T cell immunodeficiency, precisely the goal of the ELYPSE-7 study.”
About the Study
ELYPSE-7 is a randomised, monocentric, double-blind Phase IIa study evaluating the impact of IL-7 immunotherapy on CD4 lymphopenia and TCR repertoire diversity, risks of severe haematological toxicity and tumor progression in metastatic breast cancer patients. Twenty-four patients will be enrolled at a single center (Centre Léon Bérard, Lyon, France) where the study is under the direction of Isabelle Ray-Coquard, MD, PhD, Principal Investigator.
The duration of the investigation for each patient will include a study drug treatment period of at least 12 weeks (including 3 x 3-week cycles of chemotherapy) and a follow-up period for a maximum of one year (or until disease progression). Chemotherapy will be extended until disease progression, unacceptable toxicity, or willingness to stop. The inclusion period is expected to be six months with the treatment period and follow-up lasting up to one year.
All patients will receive standard anti-cancer therapy prescribed for second line metastatic breast cancer patients: XELODA (capecitabine) at an oral dose of 2500mg/day for 14 days over a 21-day cycle period. In addition, all patients will be randomly allocated in a factorial design to one of the following four study arms:
Arm 1: (Placebo Group) Patients will receive Placebo before the start of chemotherapy (at D0, D7 and D14) and during the 3rd cycle of chemotherapy (D63, D70 and D77). Arm 2: (Pre-IL-7 Treatment Group) Patients will receive CYT107 (one subcutaneous injection at 10 µg/kg/week for three weeks) before the 1st cycle of chemotherapy (at D0, D7 and D14) and will receive the placebo during the 3rd cycle of chemotherapy (D63, D70 and D77). Arm 3: (Concomitant IL-7 Treatment Group) Patients will receive Placebo before the 1st cycle of chemotherapy (D0, D7 and D14) and will receive CYT107 (one subcutaneous injection at 10 µg/kg/week for three weeks) during the 3rd cycle of chemotherapy (at D63, D70 and D77). Arm 4: (Pre- and Concomitant IL-7 Treatment) Patients will receive CYT107 (one subcutaneous injection at 10 µg/kg/week for three weeks) before the 1st cycle of chemotherapy (D0, D7 and D14) and again (one subcutaneous injection at 10 µg/kg/week for three weeks) during the 3rd cycle of chemotherapy (D63, D70 and D77).The primary endpoint of the study is the evolution of patient CD4 counts from D0 to W12 with repeated measures at D0, W3, W9, and W12. This will help in defining the optimal schedule of CYT107 administration during chemotherapy, based on the restoration of patient CD4 counts.
Secondary endpoints include the impact of CYT107 treatment on the incidence of severe hematological toxicity as indicated by the number of patients experiencing any type of hematological Adverse Event (including anemia, thrombopenia, lymphopenia, or neutropenia) of Grade ≥ 3 from D0 to W12. At this stage, the quality of T cell repertoire diversity reconstitution will also be assessed.
About Metastatic Breast Cancer
Breast cancer is the second most frequent cancer in the world, and is by far the most common malignant disease in women (22% of all new cancer cases). Worldwide, the ratio of mortality to incidence is about 36%. It ranks fifth as a cause of death from cancer overall (although it is the leading cause of cancer mortality in women — the 370,000 annual deaths represent 13.9% of cancer deaths in women). In the United States alone, the American Cancer Society estimates that more than 182,400 women will be diagnosed with breast cancer each year, while 40,480 women will lose their lives to this disease. Breast cancer will affect one of every eight American women in their lifetime and is second only to lung cancer as the leading cause of cancer deaths among women in the United States.
Metastatic or advanced breast cancer (frequently referred to as breast cancer stage 4) is the presence of disease at distant sites in the body such as the bone, liver, or lung. Symptoms may include pain from bone metastases, breathlessness from spread to the lungs, and nausea or abdominal discomfort from liver involvement. It is the most prevalent cancer in the world today and there are an estimated 3.9 million women alive who have had breast cancer diagnosed in the past 5 years (compared, for example, with lung cancer, where there are 1.4 million alive). The true prevalence of metastatic disease is high because some women live with the disease for many years. Since 1990, there has been an overall increase in incidence rates of about 1.5% annually.
The main reason patients with breast cancer fail treatment is relapse. Relapse of breast cancer occurs because the high-dose chemotherapy used in its treatment is unable to kill all the cancer cells in the patient, leaving residual disease which results in relapse.
Following treatment failure with first line chemotherapy agents, the standard reference treatment for second line metastatic breast cancer is a chemotherapeutic regimen with XELODA in combination with docetaxel is indicated for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy.
About Recombinant Human Interleukin-7 (CYT107)
Recombinant human interleukin-7 (CYT107) is a critical immune-modulator for immune T-cell recovery and enhancement. As a growth factor and cytokine physiologically produced by marrow or thymic stromal cells and other epithelia, IL-7 has a critical and, at some steps, a non-redundant stimulating effect on T lymphocyte development, notably on thymopoiesis and, downstream from the thymus, on homeostatic expansion of peripheral T-cells.
Photography (Nikon)
List Price: $2,499.95
- Stores images on CF cards or Microdrive; powered by EN-EL3a or EN-EL3 rechargeable lithium-ion battery (includes EN-EL3a battery and charger)
- RAW and JPEG capture; burst mode allows for capture of three frames per second for up to 144 pictures
- Body only; lens must be purchased separately
- 2.0-inch LCD display; power-up time of approximately 0.2 seconds
Read more about Nikon D70S 6.1MP Digital SLR Camera (Body Only)
USB Sync and Charging Cable Compatible with Apple iPhone (White)
CE (Oriongadgets)
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- For Apple iPhone, iPod Sync data or charging
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Read more about USB Sync and Charging Cable Compatible with Apple iPhone (White)
D70 training
d70 training vid
What 1 additional Nikon dSLR d70 lens would you recommend as a must have?
Currently have the following 2 lenses for the Nikon d70;
Nikor AF 28-80 f3.5-5.6 Zoom and
Nikor AF 70-300 f4-5.6 Zoom
Is there one lens you would recommend as a must have that I do not already have?
You have the zoom ranges covered from normal to tele. Once you figure crop factor you really do not have a wide angle or a good fast lens. I would say the 50 mm 1.4 or 1.6 for a fast lens and if mmoney allows the 14-24mm f/2.8, If money is a concern because that lens costs more than your camera did ( and isn't it for most of us) make that the Nikon 12-24mm f/4 )
I am going to assume you do not derive an income from photography and want to spend less than $600, judging by your current arsenal.
If you want to shoot macros, I would look at getting a long focal length macro lens that does 1:1 (you can fill the frame with the image of something that is the size of the sensor in your camera). The macro lens should be f/2.8 and at least 60mm length (ideally longer than 85mm). That will allow you to get great detail from a small subject and blur the background out.
If you shoot indoor portraits often, you should look at a very wide aperture 50mm lens (f/1.8 or f/1.4) and/or an external flash (it can be a cheap off-brand flash because you will never point it directly at the subject, you will always angle it off and use a diffuser). OEM (Nikon/Canon) Brand Flash is 2-to-10x the price of a usable off-brand flash.
For either of the above suggestions, you could go Sigma, Tamron, or Nikon/Nikkor. I would search for a review of all the lenses applicable to a specific type of shooting, after determining what kind of shooting I'd want to do.
Lastly, if you like to shoot landscapes or architecture, consider the Tokina 11-16mm f/2.8 wide angle lens. This is not a fisheye. It gives very wide angles with very low distortion. You will not find wider wide angle that is not a fisheye... and you will not find a comparable wide angle in terms of image quality, for under $800.
Before you get any of these, if you don't have a tripod already... a tripod is more important than any of the aforementioned lenses and flashes. A tripod will get you clearer shots from your 70-300 at longer focal lengths and give you the ability to do HDR and panoramic stitches as well as long exposure night shots.
Get a tripod and a remote shutter release switch. Do a search on HDR, panoramic stitch, and star trails to see what I am talking about.
I know this is a lot of information, because the question left things wide open; but I hope that it helps you out. Good luck!
Here is an interesting take on wide-angle lenses:
http://www.kenrockwell.com/tech/how-to-use-ultra-wide-lenses.htm
Thom Hogan (bythom.com) has a mantra for scenic photographs; "Near, middle, far", indicating points of interest in the photo to draw the eye into the image. That's tough to do when not using a wide-angle.
Well, that's my two cents worth. Good luck and good shooting.
What is the best lens to capture wide landscape with a Nikon D70?
I have a Nikon D70 and its lens 28/135, that is good enough, but I guess that it's not a good choice for wide landscapes. What will you recomand me?
You Should Get This Lens:
The Nikkor 12-24mm Wide Angle lens..
http://www.amazon.com/Nikon-12-24mm-Autofocus-Nikkor-Zoom/dp/B000092M1T/ref=pd_bbs_sr_1?ie=UTF8&s=electronics&qid=1214917029&sr=8-1
However, you didn't leave us a budget, so we don't know exactly how much you're willing to spend, that lens is 895$, which is more expensive than getting another d70. But, if you have the money, you need to get it, that's the best lens for landscape and wide-angle photography.
However, if you don't want to spend that much, you can just get this lens: it's a Sigma 10-20mm lens: it's actually a more wide angle lens the the 12-24mm lens:
http://www.amazon.com/Sigma-10-20mm-4-5-6-Digital-Cameras/dp/B0007U00XK/ref=pd_cp_e_1?pf_rd_p=250314001&pf_rd_s=center-41&pf_rd_t=201&pf_rd_i=B000092M1T&pf_rd_m=ATVPDKIKX0DER&pf_rd_r=01X3MEG7KF2F11FGPK8W
it's 498$, but i think lenses deserve the indulgence, don't you?
for more nikkor lenses, look on :
http://amazon.com
Have fun
What is the best quality lens for Nikon d70?
I have the original lens that comes with the Nikon d70, but I’m getting a new one and I would like to know which is the best? Do lenses really affect the pixels? I really want more professional looking photos. Any tips on which lens I should go for would be greatly appreciated.
For more professionally looking photos you need a more professional photographer, not a more professional lens. Each lens serves its own purpose. There is no single "best lens" that will work great in all situations. The current most versatile Nikon lens is 18-200mm VR, which covers huge range of focal lengths, has good vibration reduction and is an all in all good lens. Cost about $650 give or take 50.
But, for BEST results you need a dedicated lens for each task. Portraits - 50mm or 85mm prime is great. Nature - go for ultra wide ones (14-20mm), sports, you need a very fast telephoto, like 70-200 f/2.8 or even longer... There are more lenses, each for its own task.
All that said, once again, let me re-state - no matter how good a lens you will buy - the best improvement to quality of your photos you can make is not by equipment, but by knowledge. Read books or take a class! That will help you much more than a $10,000 worth of professional grade lenses.
Just consider this - if you buy a really good guitar, do you think your music will automatically become the next great hit? Or if you get a set of professional pain brushes - will the paintings you make with them be displayed in the best museums? Probably not. While taking a photograph is much easier than playing music or painting, the story is going to be the same (which many people don't realize, thinking that pressing the button is all there is to photography). Getting professional equipment won't make you a professional photographer!
LEM.
P.S. Lenses don't affect number of pixels - that's in your camera. But the do affect quality. Better lenses will produce better quality image overall, but that's technical quality. But if you don't know how to set-up a shot, make good use of available light or create your own lightning, and how to set the camera, I'm afraid it won't help too much!
What speedlight should I get for my Nikon D70. I want to get a decent one, but not spend the earth.?
As I have Nikon camera I know that Nikon flashes will be compatiable - I'm just wondering if anyone else has a D70 and what speed light / Flash gun they could recommend. I want to try and keep it under $500
Thanks in advance!
The SB-600 would, IMO, be your best choice. It offers the tilt and swivel head which the SB-400 does not have and the SB-600 is lower in price than the SB-800.
The SB800 gives you more remote flash commander controls, but in most photographic situations, I've found the SB600 to be all the flash I've needed.
http://www.kenrockwell.com/nikon/sb600.htm
Nikon D70 - how to tigger a slave with the built-in flash?
I have some studio strobes with an optical slave trigger. I want to use the built-in flash on my D70, but I don't want the built-in flash to contribute to the exposure. How can I rig that up?
The Nikon D70 uses an i-TTL system. Unfortunately, this system uses a pre-flash, so you need to forget about i-TTL.
Instead, you need to go into the D70 menu system (item 19) and switch the popup flash to manual. Set it to the lowest power possible. This will eliminate the preflash, but it will still be strong enough to trigger the studio strobes. If you are really concerned about even this amount of light from the flash in manual, then tape a piece of unexposed film over the popup flash, so that only IR gets through to set off the strobes (no visible flash to affect the exposure).
Alternatively, use an IR sender unit (link below) which fits in your hotshoe and triggers the strobes via an IR "flash".
you can also try reflecting it to the ceilling with aluminum foil taped at an angle.
Here is a review on a Cactus V2s: http://martybugs.net/reviews/cactus.cgi
Or you can go for PocketWizards (Which i prefer, and use myself), and these work with most any type of flash, but are MUCH more expensive! ($160 a unit).
Which is the best camera body, my older Nikon D70 or my girl friends younger D40?
My D70 has a 18-135 and the D40 has 18-70 but the lens are interchangeable so not the main issue.
The real question is who is the better photographer. Both cameras have the technical capability to take equally good images.
"Best" is a personal opinion. Depends on what is important to you.
They both are 6MP. I believe they use the same CCD sensor. Both use 12-bit A/D converters. No difference here.
D40 has a much smaller body. That's a big plus for me.
D70 can handle a wider variety of lenses due to the focus motor in the body. The D40 can only autofocus the newer lenses with the focus motor in the lens. Both cameras can use F-mount lenses going back decades if you don't mind manually focusing. Since my old F-mount lenses can't autofocus, this isn't an issue for me.
D40 has a better preview screen.
D70 probably has a better exposure meter. The D40 exposure meter is sub par. Nikon testers much have been on nasty drugs to come up with the D40 exposure table.
D40 can't do exposure bracketing. Sucks for folks who like to do HDRI.
D70 has 5 focus areas. D40 has 3.
D40 can display a color histogram with 3 button pushes. Not sure if the D70 has that option.
D40 can take 2000+ shots per battery charge if you don't use the flash. I believe the D70 is rated the same.
What is the price of nikon d70, d80 and d90 in india latest price please of all of these 3 cameras?
please mention the price of
nikon d70
nikon d80
nikon d90
in indian rupees please mention the latest market price of all these digital cameras individually.....
please mention the latest price
See the link below to check the prices of various Nikon models in India. For D70 you'll have to look in the archives.
Nikon D80 -
Body: INR 52,950. Body with Kit: INR 70,950
Nikon D90 -
Kit: INR 83,950. Body Only: INR 64,950
Apart from these, you can buy from the grey market too at lower prices (but be careful in what you buy and think about the kind of service you require later on).
Why did my D70 all of a sudden start working perfectly?
Will it be reliable?
Just got it back from the factory and along with my white lighting lights it works great. Plus it seems Nikon updated a few things inside my camera.
Congratulations. Sounds like Nikon did a full tuneup and update, while they did the necessary repair.
how can you connect a nikon d70 to a computer so that you can immediately view the images while shooting?
i have a nikon d70 and i would like to connect it to a computer so that i could view the images immediately on the computer and not the tiny display on the computer. how could i set that up without having to take out the card and transfer the data every time? i know that professionals do it for studio shots, and was wondering if there is a way that i could do it too.
If your main concern is viewing the images as opposed to saving them immediately to the hard drive, then I would use your video cable and a small flat screen television/monitor. For instance, I have an LCD television/computer monitor which has a regular video input. I set that up near my camera and plug the cable into the video output of the camera and the video input of the TV. Essentially, the TV replaces the small screen on back of your camera. When you shoot a photo, it will display on the TV instead of your camera LCD. You can delete the images you don't want and keep the rest on your card for downloading to your computer later. This setup works great if you are shooting from the same location with your camera on a tripod, like school portraits. Some laptops may have a video input you can use, but I don't use one and I'm not very familiar with their features.
Hope this helps!
Can I use the screen to view/shoot when taking pictures instead of the lens w/my Nikon D70?
A friend is interested in buying my Nikon D70. He doesn't want to look through the lens, he wants to use the screen like you would on a regular point and shoot digital camera.
Do you know if that is possible and how to do it?